nonlinear regression analysis (sigmoidal dose–response fitting with variable slope (four parameters)) using graphpad prism 6.0 software Search Results


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Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P z analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC50 values were calculated using a <t> nonlinear dose response model </t> in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.
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Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P z analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC50 values were calculated using a <t> nonlinear dose response model </t> in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.
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Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P z analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC50 values were calculated using a <t> nonlinear dose response model </t> in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.
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Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P z analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC50 values were calculated using a  nonlinear dose response model  in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.

Journal: European journal of medicinal chemistry

Article Title: Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors

doi: 10.1016/j.ejmech.2018.08.052

Figure Lengend Snippet: Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P z analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.

Article Snippet: The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Techniques: Inhibition

Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P 1 analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC 50 values were calculated using a  nonlinear dose response model  in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined

Journal: European journal of medicinal chemistry

Article Title: Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors

doi: 10.1016/j.ejmech.2018.08.052

Figure Lengend Snippet: Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P 1 analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined

Article Snippet: The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Techniques: Inhibition

Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P x /P y analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC 50 values were calculated using a  nonlinear dose response model  in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.

Journal: European journal of medicinal chemistry

Article Title: Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors

doi: 10.1016/j.ejmech.2018.08.052

Figure Lengend Snippet: Cytotoxicity and inhibition of human proteasomes (hCP) measured in Jurkat lysate for P x /P y analogs. Assays were performed in biological triplicate (n=3) and confirmed in technical triplicate. The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD. ND: Not determined.

Article Snippet: The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Techniques: Inhibition

Inhibition of the hiβ5 subunit of the immunoproteasome by selected analogs. IC50 values for proteasome inhibition measured in purified human immunoproteasomes at a concentration of 8 μg/mL. IC50 values were calculated from dose-response curves generated from assays performed in biological triplicate using β5 substrate Suc-LLVY-AMC. The values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Journal: European journal of medicinal chemistry

Article Title: Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors

doi: 10.1016/j.ejmech.2018.08.052

Figure Lengend Snippet: Inhibition of the hiβ5 subunit of the immunoproteasome by selected analogs. IC50 values for proteasome inhibition measured in purified human immunoproteasomes at a concentration of 8 μg/mL. IC50 values were calculated from dose-response curves generated from assays performed in biological triplicate using β5 substrate Suc-LLVY-AMC. The values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Article Snippet: The IC 50 values were calculated using a nonlinear dose response model in GraphPad Prism 6.0 and are reported with the corresponding SD.

Techniques: Inhibition, Purification, Concentration Assay, Generated